Multiple Sclerosis In The Crossfire 2007: Focus on Imaging
Faculty
Leading neuroimaging specialists— Discuss the international evolution and current role of MRI in the way we diagnose and manage MS.
In The Crossfire 2007: Faculty
Omar Khan, MD, FRCP, Moderator
Disclosure
Consultant/Research Support: Teva NeuroscienceBiography
Professor of Neurology,
Wayne State University School of Medicine,
Director, Wayne State University MS Clinical Research Center,
Director, Multiple Sclerosis Clinic, Detroit Medical Center, Detroit MI
Dr. Omar Khan is Professor of Neurology at Wayne State University School of Medicine, in Detroit, Michigan. He is the Director of the Wayne State University Multiple Sclerosis Clinical Research Center, with over 3000 patients in the MS Clinic.
Dr. Khan has published over 200 peer-reviewed papers, abstracts, and book chapters. He has received numerous awards, and has served as faculty for the American Academy of Neurology, and the European Charcot Foundation for Multiple Sclerosis Research. Dr. Khan is an elected member of the American Neurological Association and also serves on the Medical Advisory Board of the National Multiple Sclerosis Society (NMSS).
Dr. Khan has served as principal investigator on several landmark exploratory and muti-center clinical trials. His areas of interest include imaging and genetics of multiple sclerosis, and developing therapeutic approaches to treat multiple sclerosis. Dr. Khan's research is supported by the NMSS, the NIH, the Department of Veteran's Affairs, and the industry.
Robert J. Fox, MD, MS
Disclosure
Consultant/Speaker/Research Support: Biogen Idec, Genentech, NovartisBiography
Staff Neurologist and Medical Director,
Mellen Center for Multiple Sclerosis,
Assistant Professor, Department of Neurology,
Cleveland Clinic Lerner College of Medicine, Cleveland, OH
Dr. Robert J. Fox is Staff Neurologist and Medical Director at the Mellen Center for Multiple Sclerosis, Cleveland Clinic Foundation. He received his medical degree from Johns Hopkins University, neurology residency training at the University of Pennsylvania, and a master’s degree in Clinical Research from Case Western Reserve University. He serves as an advisory committee member and principal site investigator for many clinical trials, including coordinating principal investigator for a Phase III clinical trial of fumarate in relapsing remitting MS. Dr. Fox’s current research interests focus on innovative MRI techniques to evaluate MS treatments and tissue recovery after injury, where he is principal investigator and co-investigator on grants funded by the NIH and National MS Society. Dr. Fox serves as a member of various advisory and review committees for the National MS Society, on the General Advisory Council for the Cleveland Clinic General Clinical Research Center, and as a consultant to the pharmaceutical industry regarding the development of new treatments for MS.
Massimo Filippi, MD
Disclosure
No relevant financial relationships to discloseBiography
Director, Neuroimaging Research Unit,
Department of Neuroscience,
Scientific Institute and University Ospedale,
San Raffaele, Milan, Italy
John Whitaker Visiting Professor
of the American Neurological Association
Dr. Massimo Filippi is Director of the Neuroimaging Research Unit at the Scientific Institute and University, Ospedale San Raffaele, Milan, Italy, as well as the John Whitaker Visiting Professor of the American Neurological Association.
Dr. Filippi is a worldwide expert in the use of MRI in clinical neurology. He is a member of various Scientific Societies and Academies, including the Scientific Committee of the Italian MS Society, the Advisory Committee on Clinical Trials of New Drugs in MS, of the National Multiple Sclerosis Society in the US, and the Task Force on the Future of MRI-based Techniques in Neurology of the EFNS. Dr. Filippi is also a member of the Editorial Boards of ,JNNP, as well as a number of scientific and medical journals (e.g. Multiple Sclerosis), and acts as a reviewer for several scientific journals. Dr. Filippi has authored or co-authored more than 400 peer-reviewed papers and is editor of several books and journal supplements.
Dr. Filippi’s research focuses on the use of MRI-based technology to improve understanding of how neurological diseases determine progressive accumulation of irreversible physical disability and cognitive impairment. His contributions to the understanding of the pathophysiology of irreversible neurological disability have resulted in significant scientific progress.
Clyde E. Markowitz, MD
Disclosure
Consultant/Speaker/Research Support: Berlex/Bayer, Serono, Pfizer, Teva Neuroscience, Biogen Idec
Research Support: BioMS, Genentech, PDL
Biography
Assistant Professor of Neurology,
University of Pennsylvania School of Medicine
Director, Multiple Sclerosis Center,
University of Pennsylvania
Philadelphia, PA
Dr. Clyde Markowitz is an Assistant Professor of Neurology at the University of Pennsylvania School of Medicine, in Philadelphia. He is an attending neurologist and Director of the MS Center at the Hospital of the University of Pennsylvania. Dr. Markowitz earned his BS in business administration and marketing at the State University of New York at Buffalo. He participated in a post-baccalaureate pre-medical program at Columbia University, and he later earned his MD from the Columbia University College of Physicians and Surgeons in New York. He also completed his internship, residency and postdoctoral research and clinical fellowship at the Columbia Presbyterian Medical Center.
Dr. Markowitz is a member of the American Academy of Neurology, the Association for Research in Nervous and Mental Disease, and the American Association for the Advancement of Science. He also serves on the professional advisory committee for his local chapter of the National Multiple Sclerosis Society. Dr. Markowitz is the author or co-author of a number of publications, and he serves as an ad hoc reviewer for Multiple Sclerosis, Neuro-Rehabilitation, Neural Repair and The Consultant.
In The Crossfire 2006: Faculty
Omar Khan, MD, MD, FRCP, Moderator
Disclosure
Consultant/Research Support: Teva NeuroscienceBiography
Professor of Neurology,
Wayne State University School of Medicine,
Director, Wayne State University MS Clinical Research Center,
Director, Multiple Sclerosis Clinic, Detroit Medical Center, Detroit MI
Dr. Omar Khan is Professor of Neurology at Wayne State University School of Medicine, in Detroit, Michigan. He is the Director of the Wayne State University Multiple Sclerosis Clinical Research Center, with over 3000 patients in the MS Clinic.
Dr. Khan has published over 200 peer-reviewed papers, abstracts, and book chapters. He has received numerous awards, and has served as faculty for the American Academy of Neurology, and the European Charcot Foundation for Multiple Sclerosis Research. Dr. Khan is an elected member of the American Neurological Association and also serves on the Medical Advisory Board of the National Multiple Sclerosis Society (NMSS).
Dr. Khan has served as principal investigator on several landmark exploratory and muti-center clinical trials. His areas of interest include imaging and genetics of multiple sclerosis, and developing therapeutic approaches to treat multiple sclerosis. Dr. Khan's research is supported by the NMSS, the NIH, the Department of Veteran's Affairs, and the industry.
Robert Zivadinov, MD, PhD
Disclosure
Consultant/Research Support: TEVA Pharmaceuticals; Biogen Idec; AsprevaBiography
Associate Professor of Neurology, SUNY at Buffalo
Director of the Buffalo Neuroimaging Analysis Center, and
Executive Director of the New York State Multiple Sclerosis Consortium
Director, Resident and Fellowship Research Program,
The Jacobs Neurological Institute, Department of Neurology, SUNY Buffalo, NY
Dr. Robert Zivadinov holds 2 MD degrees, one from the University of Rijeka in Croatia (1993) and the other from the University of Trieste, Italy (1995). He has also earned two advanced degrees in Neurology, a M.Sc. (1995) and a Ph.D. (2002), both from the University of Rijeka.
Dr. Zivadinov has acquired extensive experience in multiple sclerosis conducting significant and progressive research, and has published more than 75 papers and 175 abstracts. He has received numerous awards from European and National Neurological Societies for his published articles, research studies and Research Fellowships.
Dr. Zivadinov is currently pursuing research studies of quantitative MRI findings in multiple sclerosis, and therapeutic interventions including strategies towards assessing neuroprotective efforts in multiple sclerosis, but he is also interested in the genetics and neuroepidemiology of MS. He has contributed chapters to five different books and has also written his own book, on brain and spinal cord atrophy in MS.
Matilde Inglese, MD, PhD
Disclosure
Consultant: TEVA Pharmaceuticals
Biography
Assistant Professor, Department of Radiology,
NYU School of Medicine
New York, NY
Dr. Matilde Inglese, MD, PhD received both her MD and PhD degrees from the University of Genoa in Italy before coming to the United States where she completed a fellowship in Neuroimaging at the New York University, NY under the mentorship of Dr. Grossman.
As a Research Fellow, Dr. Inglese employed proton MR spectroscopy to see if the technology could be used as a surrogate marker for progression and prognosis of multiple sclerosis. In one study comparing normal-appearing white matter of RR-MS patients with healthy volunteers, Dr. Inglese found elevated choline and creatine, reflecting microscopic inflammation/ demyelination and remyelination, thus confirming that abnormal metabolic activity is present during the clinically silent phase of the disease.
In another study, Dr. Inglese found an average 22% difference in the whole-brain NAA concentration between MS patients and healthy volunteers, suggesting that the conventional definition of MS as a white-matter disease may warrant reconsideration.
Dr. Inglese is author and co-author of more than 60 papers published in the neurological and radiological scientific literature. As an Assistant Professor in the Department of Radiology at NYU School of Medicine, Dr. Inglese’s research continues to investigate the clinical application of integrated multimodal high-field MR structural, chemical and functional techniques to the evaluation of patients with brain disorders, especially MS.
Daniel Pelletier, MD
Disclosure
Consultant: Glaxo Smithkline
Biography
Assistant Professor of Clinical Neurology,
UCSF School of Medicine
San Francisco, CA
Dr. Daniel Pelletier is a clinician-scientist born and educated in the Province of Quebec, Canada. After first receiving a bachelor degree in Computer Sciences and studying a year in Artificial Intelligence at the University of Connecticut, Dr. Pelletier received his M.D. degree and completed his Neurology training in Quebec City at Laval University. He subsequently received research training in multiple sclerosis and advanced magnetic resonance imaging techniques at the Montreal Neurological Institute, Canada. He joined the University of California, San Francisco MS Center in 1999 as a clinical instructor and a recipient of a National Multiple Sclerosis Physician Award Grant for his work in molecular imaging. He received the Harry Weaver Neuroscientist Scholar Award in 2005 from the National Multiple Sclerosis Society for his research on magnetic resonance spectroscopy at high field strength.
Dr. Pelletier receives extra-mural research funding from the National Multiple Sclerosis Society, National Institute of Health, and the Immune Tolerance Network. His work has recently been published in The New England Journal of Medicine, Brain, Annals of Neurology, British Medical Journal, Neuroimage and Magnetic Resonance in Medicine.